Jian Hu, MD, PhD

MD, PhD

Jian Hu

Undergraduate

Third Military Medical University,
Chongqing, 400038, P.R. China
Bachelor of Medicine
09/1979 – 07/1984

Medical School

Research Institute of Surgery,
Third Military Medical University,
Chongqing, 400042, P.R. China
Ph.D., Medical science (Neuroscience)
09/1992 – 12/1995

Third Military Medical University,
Chongqing, 400038, P.R. China
M.D. Medicine

Residency

Physical Medicine & Rehabilitation
Chief Resident (1/07-12/07) PGY 2-4 Resident
UT Southwestern Medical Center
Dallas, Texas
07/2005 – 06/2008

Department of Orthopaedics & Traumatology
Chief Resident,Resident
Southwest Hospital
Third Military Medical University
Chongqing, China
08/1984 – 11/1990

Fellowship

Pain Medicine Fellowship Program
Clinical Fellow, PGY5
Department of Anesthesiology
University of Pittsburgh Medical Center
Pittsburgh, PA
07/2010 – 06/2011

Internship

University of North Dakota SOM&HS
Internship, Preliminary Year
Department of Surgery
501 North Columbia Road
Grand Forks, ND
07/2004 – 06/2005

Professional Memberships

The American Academy of Pain Medicine (AAPM)

The Georgia Society of Interventional Pain Physicians (GSIPP)

American Academy of Physical Medicine & Rehabilitation

Association of Academic Physiatrists

Licensure

Georgia License
Active
11/01/2007 – 06/30/2017

Texas License
Active
08/29/2008 – 08/31/2017

California License
Retired
12/28/2007 – 06/30/2017

 

Research / Publications

Publications in Peer-Reviewed Journals

  • Xiaoming Peng, Zhigang Zhou, Jian Hu, David J. Fink, Marina Mata. Soluble Nogo receptor downregulates expression of neuronal Nogo-A to enhance axonal regeneration. J Biol Chem. 2010 Jan 22;285(4):2783-95. Epub 2009 Nov 9.
  •  Shuanglin Hao, Jian Hu, David J. Fink. Transgene-mediated enkephalin expression attenuates signs of naloxone-precipitated morphine withdrawal in rats with neuropathic pain. Behavioural Brain Research 2009 Jan 30; 197(1):84-9.
  • Darren Wolfe, Shuanglin Hao, Jian Hu, Rahul Srinivasan, James Goss, Marina Mata, David J. Fink, Joseph C. Glorioso. Engineering an endomorphin-2 gene for use in neuropathic pain therapy. Pain. 2007 Dec 15; 133(1-3):29-38.
  • Jian Hu, Marina Mata. Hao Shuanlin. Gui Zhang. David J Fink. Central sprouting of uninjured small fiber afferents in the adult rat spinal cord following spinal nerve ligation. European Journal of Neuroscience. 20(7): 1705-12, 2004 Oct.
  • Atsushi Natsume, Darren Wolfe, Jian Hu, Shaohua Huang, Veljko Puskovic, Joseph C. Glorioso, David J. Fink, Marina Mata. Enhanced functional recovery after proximal nerve root injury by vector-mediated gene transfer. Experimental Neurology. 184(2): 878-86, 2003 Dec.
  • Jian Hu. David J Fink. Marina Mata. Microarray analysis suggests the involvement of proteasomes, lysosomes, and matrix metalloproteinases in the response of motor neurons to root avulsion. European Journal of Neuroscience. 16(8): 1409-16, 2002 Oct.
  • Jian Hu, Ying Huang, Yan Xu, Pei Tang. Low temperature expression of transmembrane domains of glycine receptor. Protein Science, 2000; Vol.9, Suppl.1 August: 62
  • Jian Hu, Martha Zegarra, Yan Xu, Pei Tang. HPLC purification of hydrophobic transmembrane peptides. Protein Science, 2000; Vol.9, Suppl.1 August: 63
  • Pei Tang, Jian Hu, Serguei Liachenko, Yan Xu. Distinctly different interactions of anesthetic and nonimmobilizer with transmembrane channel peptides. Biophysical Journal, 1999; Vol.77, Augest : 739-746.
  • Yan Xu, Jian Hu, Zubrzycki I, Pei Tang. NMR structures of M2 segment of human glycine receptor and its anesthetic-insensitive mutant. Anesthesiology, 1999; 91(3A), Suppl. S Sep: A356
  • Pei Tang, Jian Hu, Yan Xu. 1H-NMR of Transmembrane M2 Segment of Human Glycine Receptor. Biophysical Journal, 1999; Vol.76 (1), February: A26.
  • Pei Tang, V Simplaceanu, Jian Hu, Yan Xu. Anesthetic and nonanesthetic interaction with cation channel peptide. Biophysical Journal, 1999; Vol.76(1), February : A276.
  • Tang Pei, Liachenko S, Jian Hu, Yan Xu. Preferential anesthetic interaction with interfacial residues of a transmembrane channel peptide. Anesthesiology, 1998; 89(3A), Suppl. S Sep. A99.
  • Li Bing-cang, Wang Zheng-guo, Zhu Pei-fang, Li Ying-yu, Hu Jian. Effects of embryonic spinal cord transplantation on reconstruction of nerve tract of injured spinal cord of adult rats. Chinese Journal of Traumatology. 1998, Vol.14(1), February, 7-11.
  • Li Bing-cang, Wang Zheng-guo, Zhu Pei-fang, Liao Wei-hong, Li Ying-yu, Hu Jian. Effects of transplanting embryonic spinal cord on the restoration of injured spinal cord conduction. Chinese Journal of Neurosurgery. 1998; 14(6): 345-349
  • Li Bing-cang, Wang Zheng-guo, Zhu Pei-fang, Hu Jian, Li Ying-yu,, Liao Wei-hong. Effects of embryonic spinal cord on the reconstruction nerve tract in injured spinal cord of adult rats:observation of silver under light microscope. Chinese Journal of Traumatology. 1998; 14(5): 270-273.
  • Hu Jian, Wang Zheng-guo, Zhu Pei-fang, Li Bing-cang, Li Ying-yu. Quantitive observation on reconstruction of host spinal cord neuropil after embryonic spinal cord transplantation with electron microscopy. Acta Academiae Medicinae Militaris Teritae, 1998; Vol.20, No. 4: 285-288.
  • Hu Jian, Wang Zheng-guo, Zhu Pei-fang, Li Bing-cang, Li Ying-yu. Histological observation on development of different transplantation tissues in the host spinal cord. Acta Academiae Medicinae Militaris Teritae, 1998; Vol.20, No. 3: 191-193.
  • Hu Jian, Wang Zheng-guo, Zhu Pei-fang, Li Bing-cang, Li Ying-yu. Effects of embryonic spinal cord transplantation on endogenous nerve growth factor in the spinal cord. Acta Academiae Medicinae Militaris Teritae, 1998; Vol.20, No. 2, 100-103.
  • Li Bing-cang, Wang Zheng-guo, Zhu Pei-fang, Li Ying-yu, Hu Jian, Liao Wei-hong. Effects of embryonic spinal cord on reconstruction of nerve tract in injured spinal cord of adult rats CB-HRP tracing under electron microscope. Chinese Journal of Anatomy. 1998; 21(4): 288-292
  • Li Bing-cang, Wang Zheng-guo, Zhu Pei-fang, Li Ying-yu, Hu Jian, Liao Wei-hong. Effects of embryonic spinal cord transplantion on recovery of blood flow at injured spinal cord in adult rats. Chinese Journal of Experimental Surgery. 1998; 15(3): 276.
  • Li Bing-cang, Wang Zheng-guo, Zhu Pei-fang, Li Ying-yu, Hu Jian, Liao Wei-hong. Changes of NT-3 mRNA by molecular hybridization during embryonic spinal cord repairing spinal cord injury of adult rats. Acta Anatomica. 1998; 29(1):14-20.
  • Li Bing-cang, Wang Zheng-guo, Zhu Pei-fang, Li Ying-yu, Hu Jian, Liao Wei-hong. Recovery effect of transplanting embryonic spinal cord on the spinal cord blood flow of injured spinal cord of adult rats. Journal of Chinese Spine and Spinal Cord. 1997; 7(5): 240.
  • Li Bing-cang, Wang Zheng-guo, Zhu Pei-fang, Li Ying-yu, Hu Jian. Effects of embryonic spinal cord on the reconstruction of nerve tract in injured spinal cord of adult rats: Observation of silverstain under light microscope. Chinese Journal of Traumatology. 1997; 13(5): 270-272.
  • Li Bing-cang, Wang Zheng-guo, Zhu Pei-fang, Hu Jian, Li Ying-yu, Liao Wei-hong. Changes of BDNF mRNA by molecular bybridization during embryonic spinal cord repairing injury of adult rats. National Medical Journal of China. 1997; 77(7): 516-520.
  • Li Bing-cang, Wang Zheng-guo, Zhu Pei-fang, Li Ying-yu, Hu Jian, Liao Wei-hong. Histopathological and ultrastructural observation of the repairing effects of transplanted embryonic spinal cord on injured spinal cord in rats. Acta Academiae Medicinae Militaris Teritae. 1997; 19(1): 21-24
  • Hu Jian, Wang Zheng-guo, Zhu Pei-fang. Experimental studies on the treatment for injuries of the spinal cord in adult rats with different tissue transplants. Acta Academiae Medicinae Militaris Teritae. 1995; Vol.17, No. 6: 514.
  • Hu Jian, Zeng Xian-zheng. Biomechanical study on bone healing in experimental limb lengthening. Chinese Journal of Surgery, 1994; Vol.32, No.3: 249-251.
  • Hu Jian, Zeng Xian-zheng, Li Qi-hong, Liu Feng-xuan. The optimal period of external fixation after tibial lengthening by metaphyseal osteotomy: An experimental study in goats. Chinese Journal of Orthopedics, 1994, Vol. 14(2): 108-111.
  • Hu Jian, Sun De-ming, Li Qi-hong, Ma Su-zhi, Zhou Zhong-an.. The treatment for nonunion of the femoral shaft (A report of 41 Cases). Chinese Journal of Traumatology, 1994; Vol.10, No.3: 136- 137.
  • Hu Jian, Zeng Xian-zheng. Treatment of multisection femoral shaft fractures (A report of 8 Cases). Chongqing Medical Journal, 1993; Vol.22 (2): 88-89.
  • Hu Jian, Zeng Xian-zheng, Li Qi-hong, Liu Feng-xuan. Histological changes after tibial lengthening with metaphyseal osteotomy in goats. Journal of Medical Colleges of PLA. 1993, Vol.8, No.1: 60-64.
  • Hu Jian, Li Qi-hong, Zeng Xian-zheng. Tibial lengthening by metaphyseal osteotomy in children (A report of 21 Cases). Chinese Journal of Pediatric Surgery, 1992; Vol.13, No.5: 259-260.
  • Hu Jian, Zeng Xian-zheng, Li Qi-hong, Li Zheng-bi. Changes of bone mineral content in experimental limb lengthening. Chinese Journal of Surgery. 1992, Vol.30, No.8: 461-463.
  • Hu Jian, Zeng Xian-zheng, Li Qi-hong, Liu Feng-xuan. Histology study of tibial lengthening with metaphyseal osteotomy in goats. Acta Academiae Medicinae Militaris Teritae. 1991; Vol.13, No.4: 335-338.
  • Hu Jian, Li Qi-hong, Zeng Xian-zheng, Liu Feng-xuan, Wang Da-yong, Wang Ai-min. Design of the metaphyseal osteotomy lengthening model in goats. Acta Academiae Medicinae Militaris Teritae. 1991, Vol.13, No. 6: 581-583.

Chapters in Books

  • Hu Jian. Rehabilitation of Burn injury. People Public Health Publisher, Beijing, China, March2015, 229-244.
  • Hu Jian. The animal models of musculoskeletal disease. Experiment animal models in clinical related research. Scientific and Technical Publisher of Sichuan, Sichuan, Chengdu, March 1998, 350-355.
  • Hu Jian. The treatment for the fractures of the distal radius by external fixation. The Principle and Clinical Application of Bone External Fixation. Scientific and Technical Publisher of Sichuan. Sichuan, Chengdu, May 1992, 81-87.

Presentations

  • Jian Hu, Spencer Brown, Jinchun Zhou, Quan-Zhen Li, Lance L. Goetz. Pro- and AntiInflammatory cytokine profile in chronic pressure ulcers in SCI patients. Congress Spinal Cord Med & Rehabil. Orlando, FL, August 2008.
  • Jian Hu, Lance L. Goetz, Spencer Brown, Jinchun Zhou, Quan-Zhen Li. Gene expression patterns in chronic non-healing wounds in SCI patients. 34th Annual Scientific Meeting of ASIA, June 19-22, 2008, San Diego, California.
  • Jian Hu, Itala M.Wickremasinghe, Jon Vandeventer. Pyomyositis and myonecrosis of gluteal muscles in spinal cord injury (A Case report). AAP Annual Meeting, February 19-23, Anaheim, CA, 2008, Poster 105.
  • Xiaoming Peng, David J. Fink, Jian Hu, Marina Mata. HSV-mediated gene transfer of the Nogo soluble receptor promotes functional recovery after dorsal root crush. Society of Neuroscience 36th Annual Meeting, Oct 14 to Oct.18 in Atlanta, GA, 2006, 585.20/OO60.
  • Jian Hu, Veljko Puskovic, Gui Zhang, David M. Krisky, Joseph.C. Glorioso, David J. Fink, Marina Mata. Mechanism of TNF SR and GDNF delivered by HSV – mediated gene transfer in protection of motorneuron death after spinal nerve crush and traction injury. Society of Neuroscience 34th annual Meeting, Oct 22 to Oct.27 in San Diego, 2004, 310.14.
  • Jian Hu. Mechanisms of neuropathic pain: Gene expression and anatomic reorganization. Seminar. Department of Neurology, University of Pittsburgh, December 12, 2003.
  • Jian Hu, Gui Zhang, David.M. Krisky, Joseph.C. Glorioso, David J. Fink, Marina Mata. Protective effect of TNFaSR and VEGF delivered by HSV-mediated gene transfer after spinal nerve avulsion. Society of Neuroscience 33nd Annual Meeting, November 8-12 in New Orleans, 2003, 602.4-T.
  • Marina Mata, Mindi Zhang, Darren. Wolfe, Jian Hu, Shaohua Huang, Joseph.C. Glorioso, David J. Fink. Gene therapy for spinal cord hemisection injury using a replication incompetent HSV vector to deliver GDNF. Society of Neuroscience 33nd Annual Meeting, November 8-12 in New Orleans, 2003, 775.4-W
  • Jian Hu, David J Fink, Marina Mata. Microarray analysis suggests the involvement of proteasomes, lysosomes, and matrix metalloproteinases in the response of motor neurons to root avulsion. Society of Neuroscience 32nd Annual Meeting, Orlando, FL November 2-7, 2002.
  • Jian Hu, Ying Huang, Yan Xu, Pei Tang. Low temperature expression of transmembrane domains of glycine receptor. 14th Symposium of the Protein Society of America, San Diego, 2000
  • Jian Hu, M Zegarra, Yan Xu, Pei Tang. HPLC purification of hydrophobic transmembrane peptides. 14th Symposium of the Protein Society of America, San Diego, 2000
    Pei Tang, Jian Hu, Yan Xu. 1H-NMR of Transmembrane M2 Segment of Human Glycine Receptor. A paper presented at 43rd annual meeting of Biophysics of America, Baltimore, Maryland, 1999
  • Pei Tang, V Simplaceanu, Jian Hu, Yan Xu. Anesthetic and nonanesthetic interaction with cation channel peptide: an NMR structural analysis. A paper presented at 43rd annual meeting of Biophysics of America, Baltimore, Maryland, 1999
  • Zhang Gui, Hu Jian, Zheng Xiangzhen. The treatment of femur neck fracture in elder patients by hip replacement. (A report of 265 cases). A paper presented at Orthopaedic Conference of Army, Haerbing, 1996
  • Hu Jian, Wang Zheng-guo, Zhu Pei-fang, Li Bing-cang, Li Ying-yu. The expression of neurotrophins and their receptors mRNA in culture fetal spinal cord neurons. A paper presented at 3rd Traumatology Conference of China, Hebei, 1995
  • Hu Jian, Wang Zheng-guo, Zhu Pei-fang, Li Bing-cang, Li Ying-yu. Localization of nerve growth factor and its receptor mRNA in acute rat spinal cord injury by in situ hybridization. A paper presented at 3rd Spinal Cord Injury Conference of Army, Kunming, March, 1994
  • Hu Jian, Wang Zheng-guo, Zhu Pei-fang, Li Bing-cang, Li Ying-yu. Influences of fetal spinal cord transplantation on the expression of neurotrophins and their receptors mRNA, A paper presented at 3rd Spinal Cord Injury Conference of Army, Kunming, March, 1994
Honors / Awards

Fellow of American Academy of Physical Medicine and Rehabilitation
10/2009

Faculty attending of the Year. Awarded to department’s outstanding attending physician and teacher, Dept. of PMR, UT Southwestern Medical Center
06/2009

Chief Resident, Department of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center at Dallas
1/07-12/07

The Second Prize for Military Progress in Science and Technology, China
08/2000

Outstanding individual in science and technique research, Third Military Medical University, China
11/1996

The Second Prize for Military Progress in Science and Technology, China
08/1995

Chief Resident, Department of Orthopedic Surgery, Third Military Medical University, China
1989-1990

Outstanding Student Award, Third Military Medical University
07/1984

Outstanding Student Award, Third Military Medical University
09/1981

Professional Appointments

Physical Medicine & Rehabilitation
Assistant Professor
UT Southwestern Medical Center
Dallas, Texas
07/2008 – 06/2010

Department of Neurology
Research Associate, In Laboratory of Dr. David Fink
School of Medicine, University of Pittsburgh,
Pittsburgh, PA
10/2000 – 06/2004

Department of Anesthesiology & CCM
Postdoctoral Fellow, In Laboratory of Prof. Yan Xu
School of Medicine
University of Pittsburgh
Pittsburgh, PA
03/1998 – 09/2000

Department of Orthopaedics & Traumatology
Vice-chief of Division, Associate Professor, Attending Physician
Southwest Hospital
Third Military Medical University
Chongqing, 400038, P.R. China
01/1996 – 02/1998

Department of Orthopaedics & Traumatology
Attending Physician, Assistant Professor
Southwest Hospital
Third Military Medical University
Chongqing, 400038, P.R. China
12/1990 – 08/1992

Professional Affiliations

 

 

Board Certification

The American Board of Physical Medicine and Rehabilitation
Board Certified
07/01/2009 – 12/31/2019

The American Board of Physical Medicine and Rehabilitation, Subspecialty of Pain Medicine
Board Certified
10/01/2011 – 12/31/2021

The American Board of Physical Medicine and Rehabilitation
Board Certified
07/01/2009 – 12/31/2019

ECFMG Certificate
10/07/2003
No. 0-641-813-1

 

Lectures

Seminar:

03/2009 Department of Physical Medicine & Rehabilitation, Grand Round
UT Southwestern Medical School
Title: “Pressure Ulcer Research Updates: – Wound Healing in Denervated Tissue”

08/2007 Department of Physical Medicine & Rehabilitation, Grand Round
UT Southwestern Medical School
Title: “Tai Chi Exercises: What do we know today?”

12/2003 Department of Neurology University of Pittsburgh, Seminar
Title: “Mechanisms of neuropathic pain: Gene expression and anatomic reorganization”

Hospital Affiliations

Piedmont Athens Regional Medical Center
St. Mary’s Hospital

Athens Orthopedic Clinic

1765 Old West Broad St. Bldg. 2, Ste. 200,
Athens, Georgia 30606

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