Author
Dr. Michael S Shuler, et al.
Journal
Journal of the American Society of Nephrology, Volume 13 – Issue 7
Summary
This study explores how angiotensin II (AngII) regulates sodium transport in proximal tubule epithelial cells. Researchers found that AngII rapidly activates calcineurin through AT-1 receptor–mediated tyrosine phosphorylation of phospholipase C (PLC), linking AngII signaling to calcium-dependent pathways that influence renal sodium handling.